Brian Jones recorded six assists in the game and is four short of tying Steve Nash's career-record of 510.
Three Santa Clara players registered double-doubles in points and rebounds. Jamie Holmes (22 points, 11 rebounds), Brian Jones (17/10) and David Emslie (14/10).
David Emslie tied a career-high with 14 points and recorded his second career double-double.
Stephen Dely suffered a severe asthma attack early in the game. He was tested and treated at San Jose Hospital and was released.
Santa Clara's 52 rebounds marked the second time this season the Broncos surpassed the 50-rebound mark in a game.
Santa Clara has won 18 or more games in three of the last four years and in six of Dick Davey's nine seasons.
Santa Clara won 10 conference games for the first time since the 1996-97 season and the fourth time in Dick Davey's tenure, the most of any coach at Santa Clara.